Tumour Evolution Inferred By Single-cell Sequencing

Low DNA Input Technologies Enable Rare Tumor Cell Sequencing
Navin’s laboratory routinely performs single-cell sequencing on DNA from extremely limited quantities of scarce and rare tumor sources to study the genetic complexity, evolution, and diversity in human cancer. evolution inferred by single-cell sequencing. Nature 472(7341):90–4. ... Fetch Content

Tumour Heterogeneity - Wikipedia, The Free Encyclopedia
Single-cell sequencing is a new technique that is valuable for assessing tumour heterogeneity because it can characterize individual tumour cells. single-cell tumour data has multiple advantages, The ability to construct a phylogenetic tree showing the evolution of tumour populations. ... Read Article

Next-generation sequencing In Breast Cancer: Translational ...
“Next-generation sequencing continues to make headway in cancer research by 13 Navin N, Kendall J, Troge J et al. Tumour evolution inferred by single-cell sequencing. 472(7341), 90–94 (2011). 14 Futreal PA. Leveraging next generation sequencing in the study of breast cancer ... Read More

Cancer Stem Cells - Cancernetwork.com
Navin N, Kendall J, Troge J, et al. Tumour evolution inferred by single-cell sequencing. Nature. 2011;472:90-4. 10. Donnenberg AD, Hicks JB, Wigler M, Donnenberg VS. The cancer stem cell: cell type or cell state? Cytometry A. 2013;83:5-7. ... Return Doc

Dabei handelt es sich um eine nichtinvasive Methode zur Beurteilung der klonalen Evolution des Tumorgenoms DNA: rivals or partners in cancer care in the era of single-cell analysis? In Single circulating tumor cell sequencing for monitoring. In: Oncotarget. 4, Nr ... Read Article

Tumour Evolution Inferred By Single-cell Sequencing
METHODS Samples. The frozen ductal carcinoma T10 (CHTN0173) was obtained from the Cooperative Human Tissue Network, and T16P and T16M were obtained from ... Return Document

MALBAC - Wikipedia, The Free Encyclopedia
Somatic evolution in cancer and This method of single cell sequencing has a vast number of applications number and single nucleotide variations of single colon cancer cells highlighted the heterogeneity present within a tumour. [1] MALBAC has been applied as a method to examine ... Read Article

Resolving Cancer Heterogeneity by Single Cell sequencing
Resolving cancer heterogeneity by single cell sequencing Mel Greaves & Carlo C. Maley Colonal evolution in cancer (2012) Nature . Single Cell Genomics Analysis The tumour evoluon inferred by the heatmap ... View Full Source

Single-Cell WGA-Next-Generation Sequencing And Its ...
Single-Cell WGA-Next-Generation Sequencing and its Applications in Microbial Ecology cells to be inferred. Single-cell sequencing promises to provide direct within cancer and tumour evolution, the role of genetic mosaicism in ... Access Document

Broad Applications Of single-cell Nucleic Acid Analysis In ...
Th e advantage of single­cell analysis over merely deep sequencing, whether for DNA or RNA, lies in the ability of the former to isolate diff erences and to phase possibly multiple diff erences within subpopu la ­ tions. Th ... Retrieve Content

An Introduction To Cancer Genomics - Bgbunict.it
An introduction to cancer genomics Ian J. Majewski The research community is producing billions of DNA sequence reads each day. We’re Tumour evolution inferred by single-cell sequencing Navin et al. (2011) Nature 472:90-94 Web resource ... Read Here

Commonly, Whole Genome sequencing (WGS) Is Performed With ...
Single cell sequencing is needed to characterize these genomic differences but has been hindered by whole-genome amplification bias, 13. N. Navin et al., Tumour evolution inferred by single-cell sequencing. Nature 472, 90 (Apr 7, 2011). 14. M. ... View This Document

Plasma-Derived Tumor DNA Analysis At Whole-Genome Resolution
Plasma-Derived Tumor DNA Analysis at Whole-Genome Resolution evolution inferred by single-cell sequencing. Nature 2011;472:90–4. evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature 2009; ... View Document

Evolution Of The Cancer Genome - Nature
Single-cell sequencing. Single-cell sequencing is a poten - Navin, N. et al. Tumour evolution inferred by single-cell sequencing. Nature 472, 90–94 (2011). 11. Yachida, S. et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. ... Get Doc

Co-survival Of The Fittest Few: Mosaic Amplification Of ...
Studies would use single cell sequencing, which provides the most detailed picture of tumor heterogeneity and clonal evolutionary history. Hicks J, Wigler M: Tumour evolution inferred by single-cell sequencing. Nature 2011, 472:90-94. 9. Snuderl M, Fazlollahi L, Le LP, Nitta M, ... Content Retrieval

Package ‘CORE ’ February 19, 2015 Tumour evolution inferred by single-cell sequencing. Nature 472(7341): 90-U119. Examples data(testInputBoundaries) Tumour evolution inferred by single-cell sequencing. Nature 472(7341): 90-U119. 6 testInputCORE Examples ... Retrieve Here

Open Questions: Development Of Tumor Cell Heterogeneity And ...
Open questions: development of tumor cell instance, where deep sequencing will make it possible to assess virtually all genomic alterations in a patient’s tumor tissue, and Tumour evolution inferred by single-cell sequencing. Nature 2011, 472:90–94. 4. Crockford A, Jamal-Hanjani M ... Return Doc

The Impact Of Tumor Heterogeneity On Patient Treatment Decisions
The Impact of Tumor Heterogeneity on Patient Treatment Decisions high depth or perhaps multiple single-cell sequencing et al. Tumour evolution inferred by single-cell sequencing. Nature 2011;472:90–4. 5. Merlo LM, Shah NA, ... Fetch This Document

RESEARCH HIGHLIGHT Co-survival Of The Ttest Few: Mosaic ...
Studies would use single cell sequencing, which provides the most detailed picture of tumor heterogeneity and clonal evolutionary history. Indeed, Figure 1. A nonlinear clonal evolution model derived from the observation of mosaic amplication of receptor tyrosine kinases ( RTKs) in ... Document Retrieval

Single Cell Research Review - Sequencing And Array-based ...
Single Cell Research (2011) Tumour evolution inferred by single-cell sequencing. Nature 472: 90-94 5. Stephens P. J., Greenman C. D., Fu B., Yang (2011) Tumour evolution inferred by single-cell sequencing. Nature 472: 90-94 100. Potter N. E., Ermini L., Papaemmanuil E., ... Get Document

RESEARCH HIGHLIGHT Co-survival Of The Fittest Few: Mosaic ...
Studies would use single cell sequencing, which provides single­cell resolution, with regard to the selected target scenario is very different from a linear clonal evolution model in which subclones from the primary clone ... Read Full Source